The Blancos have posted in a statement on their official website: “Real Madrid CF informs that our player Raphael Varane has given a positive result in the Covid-19 test that has been carried out this morning.”
Any player testing positive for coronavirus has to take in a period of self-isolation.
That quarantine window has been longer than a week throughout a global pandemic, meaning that Varane is also set to miss out on a trip to Anfield.
Real are due on Merseyside next Wednesday, with a place in the semi-finals of elite European competition being chased down.
Along with being forced to sit out a double header with Liverpool, the France international will also be absent for a Clasico encounter with arch-rivals Barcelona.
Zidane’s side are set to play host to old adversaries on Saturday in a contest that could have a major impact on the Liga title race.